Italy wing Angelo Esposito touched down in each half to help Benetton to a 27-14 victory over Zebre in the Guinness PRO14's Italian derby.
Hame Faiva and Edoardo Gori also crossed to secure the try-scoring bonus point at the Stadio Monigo.
Zebre were hamstrung by the 47th-minute red card shown to flanker Johan Meyer, who was punished for kicking lock Dean Budd on the floor.
Budd was sin-binned for pulling Meyer at the same time, but his return 10 minutes later meant Zebre played a large chunk with a man disadvantage.